Here's another one that made immediate sense to the original listeners. "Coughlin-ites" refers to followers of Charles Coughlin. Although he is obscure to us, Coughlin was the most popular radio speaker in the US during the 30s and early 40s (more than 40 million listeners, according to the infallible Wikipedia entry). Saying "Coughlin-ites" was something like saying "Ditto-heads" or "Limbaugh-ites" today. But Coughlin was sadly an anti-semitic Nazi sympathizer who blamed the escalating European conflict on England rather than Germany.
In this cartoon, labels help identify the topic. Pearl Harbor and Manila on a couple of bricks show that Dr. Seuss is talking about the Japanese attacks that brought the US into WWII. Dr. Seuss, like others from his time, clearly felt that Japan's unannounced and unprovoked attacks broke the rules of warfare - and now it was time to take up some of the same dirty tricks? There are only a few symbols here: the top hat as a symbol for the US and a swastika for Hitler. Is the main figure an eagle, America's symbol? or is it a chicken, symbolizing fear? Note another culturally-bound image: Hirohito is portrayed in a manner many would now regard as racist. But is Seuss racist? Reading his other cartoons makes me think not - he was in favor of civil rights for African Americans long before it was popular.
You can see the relevance for studying Revelation: we cannot understand the meaning of symbols, such as the beast, 666, Babylon, the two witnesses, or any others, unless we know how people perceived those symbols in the ancient world. We also could easily misread the impact of certain images. Just as we might (mis)read Seuss as racist, rather than opposed to the aggression of Japan, some scholars (mis)read Revelation as anti-semitic, rather than responding to first-century Jewish-Christian tension.